Highly dispersed dry sodium chloride aerosol (halo-aerosol) of certain concentration range (from 1 to 10 mg/m3) with controlled parameters is the main acting factor of controlled HT. The majority of the particles, at least 80%, in generated aerosol environment are that of the respirable size (i.e. particles of 1—5 microns), which acts most effectively in all segments of respiratory tract.
Due to the dispergational method of dry aerosol formation through a powerful mechanical impact on the salt crystals, such particles receive high surface energy and negative electrical charge. Certain physical-chemical properties of dry aerosol determine the nature of HT method, that is distinguished by a multi-component therapeutic effect of extremely small doses of the substance.
Aerosols, that contain a lot of particles larger than 5—6 microns in size, are not efficient for respiratory tract. At the same time, they can cause irritation and hyperactivity, especially with the patients prone to bronchospasmus. Aerosols, which contain large particles of dry salt aerosol (5-6 microns or larger), cause irritation of the upper respiratory tract (particularly with the propensity for mucosa atrophy) and integuments.